Modern Scientific Press

ABSTRACT: The key precursor 2-((dimethylamino)methylene)-3-oxo-N-(pyridin-2-yl)butanamide (2) was synthesized and subjected to react with cyanomethylbenzothiazole, cyanomethylbenzimidazole, 3-oxo-3-phenylpropanenitrile (9), guanidine (12), ethyl cyanoacetate (15a), 2-cyanoacetamide (15b), phenyl hydrazine and 2-aminoprop-1-ene-1,1,3-tricarbonitrile (19) to afford fused and binary heterocycles 5, 8, 11, 14, 17a, 17b, 18 and 22, respectively. On the other hand, pyridinone 23 was obtained upon reaction of anilide 1 with enamine 2 in ethanol and reacted with 2-benzylidenemalononitrile and hydrazine hydrate to give pyran and pyrazolopyridine derivatives 25 and 26, respectively. The newly synthesized compounds were characterized by elemental analyses and spectral data (IR, 1H NMR and mass spectra). The newly synthesized compounds were screened for their ABTS antioxidant and antitumor activities using Vitamin C and 5-fluorouracil as drug references, respectively. The results revealed that the tested compound 5 showed the highest antioxidant activity compared with Vitamin C and the other rest of compounds exhibited moderate to low activities.

ABSTRACT: 2-Methylquinazolin-4(3H)-one (1) and 3-amino-2-methylquinazolin-4(3H)-one (9) were used as key intermediates for the synthesis of different quinazolinone derivatives. From the antioxidant results, the carbonyl compounds such as ??????-hydroxy-??????,??????-unsaturated ketones are the major products than oil without additives (i.e. additives 3, 4, 5 and 14). On the other hand, additives 2, 10, 11, 12 and 13 indicated that the major products were hydroxyl- and keto-(unsaturated esters), so, their acid values are less than other compounds. On the other hand, all the synthesized compounds were tested as corrosion inhibitors experimentally for lube oil using three types of metals Cu, Al and Fe.

ABSTRACT: Azo pyrazolyl dyes constitute a fascinating class of azodyes exhibiting a variety of novel dyeing properties. Changes in their structure have offered a high degree of diversity of molecules that may be endowed with better dyeing properties such as PO13 (21110), PO34 (21115), PR37 (21205), PR38 (21120), PR41 (21200), and PR111. These dyes have been applied to a very large number and variety of fibres and have therefore achieved an importance which is probably greater than the weights used would suggest. The connection between dyeing and fastness properties on the one hand and chemical constitution on the other is in general indefinite. Some factors affecting the current application of these dye types are examined and future developments are considered.

ABSTRACT: A variety of new fused heterocyclic rings incorporating pyrrolo[2,1-b]benzothiazole moiety were synthesized by reaction of 2-oxo-1,2-dihydrobenzo[d]pyrrolo[2,1-b]thiazole-3-carbonitrile (2) with hydrazine, guanidine hydrochloride, thiourea, benzaldehyde, benzylidene maolnonitrile, and ethylene diamine. The structures of the newly synthesized compounds are established on the basis of chemical and spectroscopic evidence.

ABSTRACT: Nanotechnology today is growing very rapidly and has infinite applications in almost everything we do. The syntheses and characterization of polysiloxane nano-particles containing surface reactive groups were achieved. The nano-particles preparation involves two steps: emulsion co-polymerization of octamethylcyclotetrasiloxane and 1,2,3,4-tetramethyl-1,2,3,4-tetravinylcyclotetrasiloxane followed by chemical crosslinking, without consuming all the vinyl groups. The remaining vinyl groups contained in the nano-polymer were converted to epoxy groups using m-chloroperbenzoic acid, producing functionalized polysiloxane nano-particles. The chemical structure of nano-polymeric siloxanes was characterized by FTIR, ¹³C and ²⁹Si solid state NMR. GPC was used for molecular weight determination. The morphology of nano-particles was studied by TEM. TEM images showed that the particles were globular with small particle size. The thermal stability was investigated by TGA which indicated high thermal stability for the prepared polymer.

ABSTRACT: Diazodization of 3-aminopyrazole 5 with NaNO₂ in HCl/AcOH afforded the diazonium salt 6, which coupled with 7, 8 or 11 in pyridine to give arylazo derivatives 9, 10, and 12, respectively. Heating of 12 in acetic acid gave the hydrazone 14. Condensation of compound 14 with 5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde 15 gave the pyrazolopyrimidine 16. Multicomponent reaction of 4-methoxy(chloro)benzaldehyde 17 or 18 and 2-mercaptoacetic acid with 5 in a mixture of pyridine/DMF afforded the thiazolidinones 20 and 21, respectively. Treatment of 5 with one or two equivalent of 2-chloro-1-phenylethanone 22 in a mixture of pyridine/DMF afforded the ethanone and bisethanone derivative 23. Cyclization of 23 under influence of phosphrousoxy chloride afforded the imidazole derivative 25. Newly synthesized compounds were screened for their antitumor and antioxidant activities. The obtained results showed clearly that most of compounds exhibited good antitumor activities and moderate antioxidant activities, while compounds 4 and 20 exhibited broad spectrum of antitumor and antioxidant activities.