ABSTRACT: The search for more nutrition sources among forest products has called for the analysis of nutritional and anti – nutritional composition of Vitex doniana. Although, Vitex doniana had been known to be very useful among people across tropical Africa and beyond, but there is lack of adequate data on its nutritional composition. The present study designed for determination of proximate, nutritional, and also anti-nutritional analysis of the leaves of Vitex doniana. Proximate compositions revealed that the leaves of Vitex doniana contain moisture content of 4.616±0.005 g, Ash content was 2.027±0.003 g, crude lipids content was3.623±0.168 g, Crude fibre content was 4.991±0.002 g, crude protein 3.423±0.033 g, and carbohydrate content found to be 36.515±0.000g. The anti-nutritional Analysis of Vitex doniana leaves revealed that, the level of the oxalate was 19.200 ± 0.280, Nitrate 287.670±6.489, Tannins 91.100±1.100, Cyanide 228.382±0.130, Phytate 20.420±0.140 respectively. It is concluded that the young leaf is highly rich in nutrients and contains the nutrient levels that fall within other popular edible vegetables. It is therefore recommended for human consumption in every household. It is also suggested that further research should be carried out on its economic status and feasibility of the leaves as feed supplement in animal feed.