International Journal of Modern Organic Chemistry
ISSN: 2166-0174 (online)Search Article(s) by:
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Table of Content for Vol. 5 No. 1, 2018

Synthesis, Antioxidant and Antimicrobial Evaluation of New Angular 6-Hydroxybenzo[f]chromene Anchored Derivatives
Mohamed A. Abozeid, Mohamed R. El-Kholany, Abdel-Rahman H. Abdel-Rahman, El-Sayed I. El-Desoky
      
 PP. 1 - 11
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ABSTRACT: 2-Amino-6-hydroxy-4-phenyl-4H-benzo[f]chromene-3-carbonitrile (1) was synthesized via efficient cascade reaction of 2,7-dihydroxynaphathalene with benzylidene malononitrile. The precursor 1 was utilized to synthesize various angular 6-hydroxybenzo[f]chromene derivatives such as benzocoumarins, benzochromenothiazinthione and arylazobenzochromenes under different reactions conditions. Although many products showed promising activities, cyanodihydrocoumarin 4 manifests outstanding antioxidant and antimicrobial activities compared to the reference drugs.