International Journal of Modern Organic Chemistry
ISSN: 2166-0174 (online)Search Article(s) by:
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Current Issue: Vol. 6 No. 1or Keyword in Title:
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Table of Content for Vol. 6 No. 1, 2019

Synthesis and Biological Evaluation of New Pyrrolotacrines for the Treatment of Alzheimer’s Disease
Hanadi Y. Medrasi, Abdellatif M. Salaheldin and Ebtisam A. Hafez
      
 PP. 1 - 13
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ABSTRACT: An efficient routes to pyrroles by the reaction of versatile enaminonitriles and aniline derivatives. Different pyrrole derivatives have been synthesized by Thorpe-Ziegler cyclization followed by its transformation into pyrrolotacrine analogues by Friedländer-type of reaction by classical heating and by microwave irradiation. The synthesized tacrine analogues were evaluated for their ability to inhibit acetylcholinesterase, using Ellman’s test, are reported.


Synthesis and Biological Activity of (Tetrahalo Metallate) Copper and Nickel Nanoparticles Stabilized by Cationic Thiol Polyurethane Surfactants
Mostafa E. Hendawy, Nabel A. Negm, Mohamed F. Zaky, Ibrahim A. Sabbah
      
 PP. 14 - 29
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ABSTRACT: Copper and nickel nanoparticles are known to be one of the multifunctional inorganic nanoparticles with effective antibacterial activity. This study aims to determine the antimicrobial efficacy of chemical synthesized copper and nickel nanoparticle against various bacterial and fungal pathogens. Grinding method is used to synthesize copper and nickel nanoparticles. In this paper, the new cationic thiol polyurethane surfactants with different alkyl chain length were synthesized (PQ8, PQ10 and PQ12). The chemical structure of the synthesized surfactants was confirmed using infra-red spectroscopy (IR) and proton nuclear magnetic resonance spectroscopy (+H NMR). The nanostructure of the synthesized surfactant with copper and nickel nanoparticles with diameters ranging from 10 to 55 nm was prepared and characterized using ultra violet spectrophotometer (UV), infra-red spectroscopy (IR) and transmission electron microscope (TEM). The results declare formation and stabilization of copper and nickel nanoparticle using synthesized cationic surfactants. Antimicrobial activity of the synthesized cationic surfactants and their nanostructure with copper and nickel nanoparticles were evaluated against pathogenic bacteria and fungi. The antimicrobial activity showed the enhancement in the antimicrobial activity of the synthesized cationic surfactants in the nanostructures form.