International Journal of Modern Organic Chemistry
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Table of Content for Vol. 6 No. 1, 2019

Synthesis and Biological Evaluation of New Pyrrolotacrines for the Treatment of Alzheimer’s Disease
Hanadi Y. Medrasi, Abdellatif M. Salaheldin and Ebtisam A. Hafez
      
 PP. 1 - 13
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ABSTRACT: An efficient routes to pyrroles by the reaction of versatile enaminonitriles and aniline derivatives. Different pyrrole derivatives have been synthesized by Thorpe-Ziegler cyclization followed by its transformation into pyrrolotacrine analogues by Friedländer-type of reaction by classical heating and by microwave irradiation. The synthesized tacrine analogues were evaluated for their ability to inhibit acetylcholinesterase, using Ellman’s test, are reported.