International Journal of Modern Analytical and Separation Sciences
ISSN: 2167-7778 (online)Search Article(s) by:
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Current Issue: Vol. 5 No. 1or Keyword in Title:
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Table of Content for Vol. 5 No. 1, 2016

Development and Validation of a Capillary Electrophoresis Method for Quality Assessment of Metronidazole-based Drugs
Serigne Omar SARR, EL Hadji Assane DIOP, Amadou DIOP, Adjidokpa Gloria S. ATOUN, Serigne Momar NDIAYE, Christelle Ange WAFFO TCHOUNGA, Rokhaya GUEYE, Khadidiatou THIAM, Thierno Mouhamed WANE, Aminata SARR, Bara NDIAYE, Serge RUDAZ, Yérim Mbagnick DIOP
      
 PP. 1 - 11
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ABSTRACT: A simple, economic and ecological capillary electrophoresis method was developed and validated for the determination of metronidazole in pharmaceutical formulations. Validation was performed by evaluating some criteria: linearity, precision, selectivity, accuracy, limits of detection and quantification. The limits of detection and quantification were 6 mg/L and 18mg/L respectively. A correlation coefficient of 0.996 was obtained in the range between 50% and 150% of the working concentration. The repeatability and intermediate precision expressed as RSD were 1.0% and1.3% respectively. The method showed also a good accuracy with recovery percentages ranging from 94.7% to 100%. Capillary electrophoresis could be a real alternative for developing countries for the quality control of medicines in view of its economic and environmental benefits.


Physico-Chemical Characterization of Industrial Effluents in Minna Niger State, Nigeria
M. B. Likita, Nura G. K, Nuhu. C. D, Isah S. D. K
      
 PP. 12 - 19
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ABSTRACT: Effluent water samples were collected from Aleb, Bakai pharmaceutical Industries and Maizube Farm at Shango, Chanchaga, and Sabon-Daga respectively all located in different parts of Minna. Three (3) samples were analyzed from each industry for Temperature, Conductivity, pH, Turbidity, Dissolved Oxygen (DO), Biochemical Oxygen Demand (BOD), Chloride, Hardness, Alkalinity, Nitrate and Total Solids. Elements; Zn, Pb, Cd, and Fe were also analyzed by Atomic Absorption Spectrophotometer (AAS) method. The results obtained for Dissolved Oxygen (DO) and Biochemical Oxygen Demand (BOD) were ranged from 2.50-4.10 ppm and 2.50-3.90 ppm, the DO, and BOD values were related with low concentration in the effluent samples. The values for hardness was ranged from 11-205 ppm, Zn value was higher than World Health Organization (WHO) standard limit of 15ppm, while the values of Cd, Pb and Fe ranged from 0.012-0.017ppm, 0.001-0.004ppm and 0.29-0.9ppm were within (WHO) standard limit of 0.003ppm, 0.1ppm and 0.3-1.0ppm respectively. The results of the analysis indicated variable concentration of the parameters analyzed with high concentration of Zn in the samples which was above threshold limit of 15ppm, excess of Zn in effluent, when leached into drinking water sources such as boreholes, well water, River water or Stream water can lead to gastrointestinal distress, nausea, fever, chills, and diarrhea.


Assessment of Heavy Metals Levels and Leaching Potentials in Dumpsites Soils in Wukari, North-Eastern Nigeria
Ojodomo J. Achadu, Ocholi I. Ochimana, Ahmadu A. Ochefu, Uzoma P. Njoku
      
 PP. 20 - 31
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ABSTRACT: In this study, we report on the analytical assessment of heavy metals contents of soils collected from different dumpsites in Wukari and environs. The levels of Cu, Cd, Pb, Fe and Zn metals were determined and the data obtained was subjected to pollution evaluation methods such as contamination factor (CF) and pollution load index (PLI). The contamination factors (CFs) revealed a moderate to extreme contamination of the dumpsites and a decreasing trend in the heavy metals concentrations was observed in soils collected at about 100 metres from the respective dumpsites which indicated some leaching of the metals from the dumpsites to adjacent environment. The pollution load index (PLI) showed that some of the dumpsites are severely polluted as the PLI of the metals from each sample site exceeded the PLI of the background (control) sample (0.2). Spearman’s rank correlation analysis showed clear correlations (p<0.001) amongst the metals suggesting a common source.